Drug-excipient compatibility studies constitute an important phase in the development stage (pre-formulation) of dosage forms. They provide information whether physicochemical interactions happen between API (active pharmaceutical ingredient) and excipients. Differential scanning calorimetry (DSC) and thermogravimetry (TGA) are fast and easy-to-use methods to get first information about drug-excipient compatibility. For that, DSC and/or TGA measurements are … Read moreFast Compatibility Check by Means of DSC and SuperPosition
Water is one of the major parts influencing our climate. Our atmosphere is filled with water. We may not always be able to see it, but it interacts with us and our materials. Learn how thermal analysis helps identify water absorption and determine water content.
The shelf-life of a pharmaceutical product concerning thermal stability can be predicted using thermogravimetry measurements and the software Kinetics Neo.
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Compressibility of a pharmaceutical substance can lead to changes in its crystal structure, and thus in its properties (bio-availability, flowability, …). A DSC measurement verifies the quality of the product after compression.
Sporting goods and toys for kids or pets are often made of flexible plastics. Some examples are sensory chewing toys, action figurines as well as balls of various kinds. A common polymer used for these applications is PVC (polyvinylchloride), because it can be made softer and more flexible by adding plasticizers. Therefore, they can evaporate or be rinsed out by saliva or sweat. Learn how to determine detect and identify plasticizers!
Drug-excipient compatibility studies are an important part during the development of a new formulation. They ensure that no interaction occurs between drug and excipients that could affect the properties, stability, efficacy of the active ingredient. Thermal Analysis is used for rapid assessment of physicochemical interactions.
How does temperature and humidity influence the quality, stability and efficacy of pharmaceuticals? Thermal Analysis provides first information.
The thermal stability of a substance is closely related to the shelf-life of pharmaceutical products. Here, the thermal stability of diclofenac sodium (anti-inflammatory) is determined by means of thermogravimetry.