Drug-excipient compatibility studies constitute an important phase in the development stage (pre-formulation) of dosage forms. They provide information whether physicochemical interactions happen between API (active pharmaceutical ingredient) and excipients. Differential scanning calorimetry (DSC) and thermogravimetry (TGA) are fast and easy-to-use methods to get first information about drug-excipient compatibility. For that, DSC and/or TGA measurements are … Read more
The shelf-life of a pharmaceutical product concerning thermal stability can be predicted using thermogravimetry measurements and the software Kinetics Neo.
Compressibility of a pharmaceutical substance can lead to changes in its crystal structure, and thus in its properties (bio-availability, flowability, …). A DSC measurement verifies the quality of the product after compression.
Drug-excipient compatibility studies are an important part during the development of a new formulation. They ensure that no interaction occurs between drug and excipients that could affect the properties, stability, efficacy of the active ingredient. Thermal Analysis is used for rapid assessment of physicochemical interactions.
How does temperature and humidity influence the quality, stability and efficacy of pharmaceuticals? Thermal Analysis provides first information.
The thermal stability of a substance is closely related to the shelf-life of pharmaceutical products. Here, the thermal stability of diclofenac sodium (anti-inflammatory) is determined by means of thermogravimetry.
When making sure pharmaceuticals comply to quality standards, there are four areas where Thermal Analysis can help to determine potential problems. This article will explain those Terms.
Thermal stability is a concept that is easy to conceive. But how to measure and quantify it? A fast and safe method for this is to use a thermobalance.
The term polymorphism comes from the Greek, “poly” meaning “multiple” and “morph” meaning “form”. Used in different areas as programming or biology, it designates the ability of a variable, of an object, of a gene to take on multiple forms. In the pharmaceutical industry, polymorphism refers to the ability of a material to exist in … Read more
Compatibility refers to harmony in a relationship, but is also an important term in science, be it in medicine where only a compatible organ can be transplanted to a recipient, or in computing to refer to software packages that can be used together. This concept is also well-known in the pharmaceutical field: Two components (e.g., … Read more