Compatibility of Drug and Excipient: Faster and Easier By Means of Thermal Analysis and SuperPosition

DSC in Pharma R&D

Compatibility refers to harmony in a relationship, but is also an important terms in science, be it in medicine where only a compatible organ can be transplanted to a recipient, or in computing to refer to software packages that can be used together. This concept is also well-known in the pharamceutical field: Two components (e.g., … Read moreCompatibility of Drug and Excipient: Faster and Easier By Means of Thermal Analysis and SuperPosition

Good Stability Versus Good Tabletability: The Choice of Modification

Many pharmaceutical solids exhibit polymorphism, i.e., the ability of a substance to exist in different crystalline forms. The polymorphic form can have significant influence on pharmaceutical processing and can, for example, affect grinding, granulation and tabletability. A DSC measurement allows for the characterization of the present modification. Here, different modifications of paracetamol are distinguished by means of DSC.

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Clever Tool for Short Cooling Times

How do nucleating agents influence the crystallization behavior of your polymer in the mold? To answer questions like these, the kinetics of the crystallization reaction is determined for mixtures of polypropylene with different nucleating agents. The results are used to carry out predictions on the product behavior for any temperature programs.

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How does water change the properties of Lactose?

Spray-dried a-lactose monohydrate is a matrix of amorphous lactose in which lactose monohydrate crystals are embedded. Humidity has no influence on the crystal but amorphous lactose is very hygroscopic: in presence of humidity, it will transform into the crystalline form. This has consequences on the tableting properties of the substance. Thermal Analysis gives you first Information about the water content of your lactose and the consequences for its compressing properties.

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