Raw material identification or incoming goods inspection is of paramount importance for the quality and safety of drug products, wherever chemical substances are used in the pharmaceutical industry – maybe as an educt of chemical reactions or as a basis for further processing.
Differential Scanning Calorimetry (DSC) offers a quick and easy way to determine the purity of crystalline substances. Only one measurement with a few milligrams of sample is needed. Read here how it works!
The increasing number of product recalls in recent months has again made us aware how important the purity of drug ingredients is. Differential scanning calorimetry (DSC) is able to quickly analyze the absolute purity of chemical compounds within a single run, without the need for a reference standard.
Paracetamol (acetaminophen) is the most commonly used medication for pain and fever in both the United States and Europe. However, it is not worth getting a headache when you think about its physicochemical properties. Thermal analysis, and especially differential scanning calorimetry (DSC), is of great help.
From the chemical point of view, diamonds are just made of carbon. The phenomenon that chemical elements can occur in different forms within the same phase, i.e., in different structural modifications, is called allotropy. Due to the relationship between crystal modification and melting point, Differential Scanning Calorimetry (DSC) is ideally suited to discriminate between different polymorphic forms. A more general term for chemical compounds is polymorphism.
Thermal Analysis, in particular DSC (Differential Scanning Calorimetry) and TGA (Thermogravimetric Analysis), provides valuable information for drug development, pre-formulation and quality control of pharmaceuticals. Learn more about the applications of Thermal Analysis in the pharmaceutical industry.
Thermal analysis equipment can be found in many analytical, development, formulation and QC laboratories. Find out why this technique is that frequently used.
– In particular for users of differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) – Installation qualification (IQ) and operational qualification (OQ) are part of the so-called analytical instrument qualification (AIQ) process at the user´s lab to confirm that an instrument is properly installed, works correctly and yields the expected results. A key term in … Read moreIQ and OQ – What Does This Mean for Thermal Analysis Users?