Clear Raw Material Identification (RMID) Using DSC

Raw material identification or incoming goods inspection is of paramount importance for the quality and safety of drug products, wherever chemical substances are used in the pharmaceutical industry – maybe as an educt of chemical reactions or as a basis for further processing.

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Monitoring the Polymorphism of Paracetamol by Means of DSC

Paracetamol (acetaminophen) is the most commonly used medication for pain and fever in both the United States and Europe. However, it is not worth getting a headache when you think about its physicochemical properties. Thermal analysis, and especially differential scanning calorimetry (DSC), is of great help.

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Studying Polymorphism by Means of DSC

From the chemical point of view, diamonds are just made of carbon. The phenomenon that chemical elements can occur in different forms within the same phase, i.e., in different structural modifications, is called allotropy. Due to the relationship between crystal modification and melting point, Differential Scanning Calorimetry (DSC) is ideally suited to discriminate between different polymorphic forms. A more general term for chemical compounds is polymorphism.

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Reliable Characterization of Pharmaceuticals Using Thermal Analysis

Thermal Analysis, in particular DSC (Differential Scanning Calorimetry) and TGA (Thermogravimetric Analysis), provides valuable information for drug development, pre-formulation and quality control of pharmaceuticals. Learn more about the applications of Thermal Analysis in the pharmaceutical industry.

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IQ and OQ – What Does This Mean for Thermal Analysis Users?

4Q - Instrument qualification

– In particular for users of differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) – Installation qualification (IQ) and operational qualification (OQ) are part of the so-called analytical instrument qualification (AIQ) process at the user´s lab to confirm that an instrument is properly installed, works correctly and yields the expected results. A key term in … Read moreIQ and OQ – What Does This Mean for Thermal Analysis Users?