Drug-Excipient Compatibility Check

Drug-excipient compatibility studies are an important part during the development of a new formulation. They ensure that no interaction occurs between drug and excipients that could affect the properties, stability, efficacy of the active ingredient. Thermal Analysis is used for rapid assessment of physicochemical interactions.

Read more

The Phenomenon Polymorphism – A Major Impact on Drug Performance

The term polymorphism comes from the Greek, “poly” meaning “multiple” and “morph” meaning “form”. Used in different areas as programming or biology, it designates the ability of a variable, of an object, of a gene to take on multiple forms. In the pharmaceutical industry, polymorphism refers to the ability of a material to exist in … Read moreThe Phenomenon Polymorphism – A Major Impact on Drug Performance

Compatibility of Drug and Excipient: Faster and Easier By Means of Thermal Analysis and SuperPosition

DSC in Pharma R&D

Compatibility refers to harmony in a relationship, but is also an important term in science, be it in medicine where only a compatible organ can be transplanted to a recipient, or in computing to refer to software packages that can be used together. This concept is also well-known in the pharmaceutical field: Two components (e.g., … Read moreCompatibility of Drug and Excipient: Faster and Easier By Means of Thermal Analysis and SuperPosition

Good Stability Versus Good Tabletability: The Choice of Modification

Many pharmaceutical solids exhibit polymorphism, i.e., the ability of a substance to exist in different crystalline forms. The polymorphic form can have significant influence on pharmaceutical processing and can, for example, affect grinding, granulation and tabletability. A DSC measurement allows for the characterization of the present modification. Here, different modifications of paracetamol are distinguished by means of DSC.

Read more

How DSC Measurements help with Phase Diagrams – A Possibility for Determining the Composition of a NiAl Alloy

FreeImages.com/mireque kodesh

E. Post, J. Blumm

A phase diagram portrays the equilibrium conditions between the thermodynamically separated phases or it shows which phases are present in the material system at different temperatures, pressures and compositions. Thermoanalytical methods play an important role in establishing binary and ternary phase diagrams. They are based on the principle that, when a phase transition occurs, the physical, chemical and/or structural properties change.

Read more