Category: Differential Scanning Calorimetry • NETZSCH

Compatibility of Drug and Excipient: Faster and Easier By Means of Thermal Analysis and SuperPosition

September 19, 2019September 19, 2019 by Claire Strasser

Compatibility refers to harmony in a relationship, but is also an important terms in science, be it in medicine where only a compatible organ can be transplanted to a recipient, or in computing to refer to software packages that can be used together. This concept is also well-known in the pharamceutical field: Two components (e.g., … Read moreCompatibility of Drug and Excipient: Faster and Easier By Means of Thermal Analysis and SuperPosition

Good Stability Versus Good Tabletability: The Choice of Modification

May 14, 2019 by Claire Strasser

Many pharmaceutical solids exhibit polymorphism, i.e., the ability of a substance to exist in different crystalline forms. The polymorphic form can have significant influence on pharmaceutical processing and can, for example, affect grinding, granulation and tabletability. A DSC measurement allows for the characterization of the present modification. Here, different modifications of paracetamol are distinguished by means of DSC.

How DSC Measurements help with Phase Diagrams – A Possibility for Determining the Composition of a NiAl Alloy

April 30, 2019 by NETZSCH Applications Laboratory

E. Post, J. Blumm

A phase diagram portrays the equilibrium conditions between the thermodynamically separated phases or it shows which phases are present in the material system at different temperatures, pressures and compositions. Thermoanalytical methods play an important role in establishing binary and ternary phase diagrams. They are based on the principle that, when a phase transition occurs, the physical, chemical and/or structural properties change.