Differential Scanning Calorimetry

Detection of Ultra-Small Residual Masses: Weigh The Little Bird!

Thermogravimetry (TGA) is frequently applied for the compositional analyses of such materials as, for example, fiber-reinforced polymer composites. The residual mass at the end of a TGA experiment reflects the filler or glass fiber content as well as the presence of impurities. By using a relatively large sample volume in a top-performing thermobalance along with the intelligent Proteus® software by NETZSCH, it is possible to detect ultra-small residual masses with concentrations down to the ppm (= 10-6) range! Such small concentrations can be illustrated by a little bird with a mass of a few grams sitting on the back of an elephant weighing a few tons.

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Efficient Substance Identification Using Identify, …

It is possible to identify substances manually by comparing their characteristic data with literature sources or with previous measurements, but it is far more effective to automatize this process and to use databases for comparison purpose. Learn here how the NETZSCH software can do this for you!

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The Role of DSC in Lyophilisation Processes

Many APIs (active pharmaceutical ingredients) or formulations, especially those based on biopharmaceuticals, are thermally sensitive and unstable in aqueous solutions. In order to achieve higher stability and longer shelf life, such drug ingredients must be dried. Learn how thermal analysis can help determine the parameters of the freeze-drying process.

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Clear Raw Material Identification (RMID) Using DSC

Raw material identification or incoming goods inspection is of paramount importance for the quality and safety of drug products, wherever chemical substances are used in the pharmaceutical industry – maybe as an educt of chemical reactions or as a basis for further processing.

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Monitoring the Polymorphism of Paracetamol by Means of DSC

Paracetamol (acetaminophen) is the most commonly used medication for pain and fever in both the United States and Europe. However, it is not worth getting a headache when you think about its physicochemical properties. Thermal analysis, and especially differential scanning calorimetry (DSC), is of great help.

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Studying Polymorphism by Means of DSC

From the chemical point of view, diamonds are just made of carbon. The phenomenon that chemical elements can occur in different forms within the same phase, i.e., in different structural modifications, is called allotropy. Due to the relationship between crystal modification and melting point, Differential Scanning Calorimetry (DSC) is ideally suited to discriminate between different polymorphic forms. A more general term for chemical compounds is polymorphism.

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Drug-Excipient Compatibility Check

Drug-excipient compatibility studies are an important part during the development of a new formulation. They ensure that no interaction occurs between drug and excipients that could affect the properties, stability, efficacy of the active ingredient. Thermal Analysis is used for rapid assessment of physicochemical interactions.

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