Clear Raw Material Identification (RMID) Using DSC

Raw material identification or incoming goods inspection is of paramount importance for the quality and safety of drug products, wherever chemical substances are used in the pharmaceutical industry – maybe as an educt of chemical reactions or as a basis for further processing.

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Monitoring the Polymorphism of Paracetamol by Means of DSC

Paracetamol (acetaminophen) is the most commonly used medication for pain and fever in both the United States and Europe. However, it is not worth getting a headache when you think about its physicochemical properties. Thermal analysis, and especially differential scanning calorimetry (DSC), is of great help.

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Studying Polymorphism by Means of DSC

From the chemical point of view, diamonds are just made of carbon. The phenomenon that chemical elements can occur in different forms within the same phase, i.e., in different structural modifications, is called allotropy. Due to the relationship between crystal modification and melting point, Differential Scanning Calorimetry (DSC) is ideally suited to discriminate between different polymorphic forms. A more general term for chemical compounds is polymorphism.

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Drug-Excipient Compatibility Check

Drug-excipient compatibility studies are an important part during the development of a new formulation. They ensure that no interaction occurs between drug and excipients that could affect the properties, stability, efficacy of the active ingredient. Thermal Analysis is used for rapid assessment of physicochemical interactions.

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The Phenomenon Polymorphism – A Major Impact on Drug Performance

The term polymorphism comes from the Greek, “poly” meaning “multiple” and “morph” meaning “form”. Used in different areas as programming or biology, it designates the ability of a variable, of an object, of a gene to take on multiple forms. In the pharmaceutical industry, polymorphism refers to the ability of a material to exist in … Read moreThe Phenomenon Polymorphism – A Major Impact on Drug Performance

Compatibility of Drug and Excipient: Faster and Easier By Means of Thermal Analysis and SuperPosition

DSC in Pharma R&D

Compatibility refers to harmony in a relationship, but is also an important term in science, be it in medicine where only a compatible organ can be transplanted to a recipient, or in computing to refer to software packages that can be used together. This concept is also well-known in the pharmaceutical field: Two components (e.g., … Read moreCompatibility of Drug and Excipient: Faster and Easier By Means of Thermal Analysis and SuperPosition