Thermal Analysis in the Characterization of Nano-based Drug Delivery Systems

Our new video series comprises contributions in various forms and aims to bring expert insights from the field of pharmaceuticals to you. Our first guest is Christian Grune, pharmacist and PhD student. His work is focused on the characterization of nano-based drug delivery systems.

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Smart Thermal Analysis: Measurements Wanted?

Imagine the typical situation in everyday laboratory work: A new sample has to be analyzed, but what are the suitable measurement conditions such as temperature program, sample mass or the right crucible? And what measurement results can be expected? Perhaps such kind of sample was already measured by you in the past ‒ or maybe by NETZSCH. Wouldn’t it help a lot to simply search in a database for thermal analysis? Identify, which is a part of the Proteus® analysis software, is the solution!

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Detection of Ultra-Small Residual Masses: Weigh The Little Bird!

Thermogravimetry (TGA) is frequently applied for the compositional analyses of such materials as, for example, fiber-reinforced polymer composites. The residual mass at the end of a TGA experiment reflects the filler or glass fiber content as well as the presence of impurities. By using a relatively large sample volume in a top-performing thermobalance along with the intelligent Proteus® software by NETZSCH, it is possible to detect ultra-small residual masses with concentrations down to the ppm (= 10-6) range! Such small concentrations can be illustrated by a little bird with a mass of a few grams sitting on the back of an elephant weighing a few tons.

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Efficient Substance Identification Using Identify, …

It is possible to identify substances manually by comparing their characteristic data with literature sources or with previous measurements, but it is far more effective to automatize this process and to use databases for comparison purpose. Learn here how the NETZSCH software can do this for you!

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The Role of DSC in Lyophilisation Processes

Many APIs (active pharmaceutical ingredients) or formulations, especially those based on biopharmaceuticals, are thermally sensitive and unstable in aqueous solutions. In order to achieve higher stability and longer shelf life, such drug ingredients must be dried. Learn how thermal analysis can help determine the parameters of the freeze-drying process.

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Clear Raw Material Identification (RMID) Using DSC

Raw material identification or incoming goods inspection is of paramount importance for the quality and safety of drug products, wherever chemical substances are used in the pharmaceutical industry – maybe as an educt of chemical reactions or as a basis for further processing.

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