Spray-dried a-lactose monohydrate is a matrix of amorphous lactose in which lactose monohydrate crystals are embedded. Humidity has no influence on the crystal but amorphous lactose is very hygroscopic: in presence of humidity, it will transform into the crystalline form. This has consequences on the tableting properties of the substance. Thermal Analysis gives you first Information about the water content of your lactose and the consequences for its compressing properties.
Each of the modifications of a polymorph has different physical properties. That´s why they have to be characterized before processing, for example using DSC.
The database system for thermal analysis by NETZSCH, called Identify, has now (from Proteus® analysis version 8.0 or higher) already more than 2000 database entries available.
Furthermore, Identify can now be used with combined TGA+DSC, TGA-c-DTA® and STA measurements, which allows for material identification with greater certainty.
AutoEvaluation by NETZSCH is a very helpful tool for evaluation of thermoanalytical measurements. The entire measurement is evaluated by AutoEvaluation automatically and autonomously (not via pre-defined macro!) – with only one mouse click – and just within a second. AutoEvaluation is available for DSC, TGA and now also for STA measurements. Furthermore, the adaptability of AutoEvaluation is adressed.