Our video series “Expert Insights into Substance Analysis” continues! Today, Dr. Joana Pinto (Research Center Pharmaceutical Engineering GmbH) introduces three examples studying the interaction of drugs and excipients using thermal analysis.
Closed indoor spaces are a problem due to the spread of SARS-CoV-2 via aerosols, especially in winter, when cold temperatures limit the ability to air rooms. A body of experts investigates the extent to which particle concentrations in enclosed indoor spaces can decreased with the help of highly effective indoor filters. The smoke density test device from NETZSCH TAURUS Instrument was also used in this context. Read more in the article!
Our new video series comprises contributions in various forms and aims to bring expert insights from the field of pharmaceuticals to you. Our first guest is Christian Grune, pharmacist and PhD student. His work is focused on the characterization of nano-based drug delivery systems.
Imagine the typical situation in everyday laboratory work: A new sample has to be analyzed, but what are the suitable measurement conditions such as temperature program, sample mass or the right crucible? And what measurement results can be expected? Perhaps such kind of sample was already measured by you in the past ‒ or maybe by NETZSCH. Wouldn’t it help a lot to simply search in a database for thermal analysis? Identify, which is a part of the Proteus® analysis software, is the solution!
Thermogravimetry (TGA) is frequently applied for the compositional analyses of such materials as, for example, fiber-reinforced polymer composites. The residual mass at the end of a TGA experiment reflects the filler or glass fiber content as well as the presence of impurities. By using a relatively large sample volume in a top-performing thermobalance along with the intelligent Proteus® software by NETZSCH, it is possible to detect ultra-small residual masses with concentrations down to the ppm (= 10-6) range! Such small concentrations can be illustrated by a little bird with a mass of a few grams sitting on the back of an elephant weighing a few tons.
The Kinetics Neo software by NETZSCH allows for advanced analytics. Learn how to predict the decomposition behavior of materials under different climatic conditions and how to estimate thermal risks and hazards.
It is possible to identify substances manually by comparing their characteristic data with literature sources or with previous measurements, but it is far more effective to automatize this process and to use databases for comparison purpose. Learn here how the NETZSCH software can do this for you!
Many APIs (active pharmaceutical ingredients) or formulations, especially those based on biopharmaceuticals, are thermally sensitive and unstable in aqueous solutions. In order to achieve higher stability and longer shelf life, such drug ingredients must be dried. Learn how thermal analysis can help determine the parameters of the freeze-drying process.
If you missed out on any of our recent rheology webinars, the good news is that you can now watch them all for free!
Raw material identification or incoming goods inspection is of paramount importance for the quality and safety of drug products, wherever chemical substances are used in the pharmaceutical industry – maybe as an educt of chemical reactions or as a basis for further processing.