AutoEvaluation is an intelligent software algorithm and part of the NETZSCH Proteus® software, which automatically and autonomously evaluates thermo-analytical measurement curves. It has already been introduced and successfully applied for Differential Scanning Calorimetry and Thermogravimetric Analysis and is also available for dL signals as generated by dilatometers (DIL) and thermomechanical analyzers (TMA). As an improvement, the mean CTE (Coefficient of Thermal Expansion) values are evaluated additionally before and after the glass transition.
Imagine the typical situation in everyday laboratory work: A new sample has to be analyzed, but what are the suitable measurement conditions such as temperature program, sample mass or the right crucible? And what measurement results can be expected? Perhaps such kind of sample was already measured by you in the past ‒ or maybe by NETZSCH. Wouldn’t it help a lot to simply search in a database for thermal analysis? Identify, which is a part of the Proteus® analysis software, is the solution!
Drug-excipient compatibility studies constitute an important phase in the development stage (pre-formulation) of dosage forms. They provide information whether physicochemical interactions happen between API (active pharmaceutical ingredient) and excipients. Differential scanning calorimetry (DSC) and thermogravimetry (TGA) are fast and easy-to-use methods to get first information about drug-excipient compatibility. For that, DSC and/or TGA measurements are … Read more
Compressibility of a pharmaceutical substance can lead to changes in its crystal structure, and thus in its properties (bio-availability, flowability, …). A DSC measurement verifies the quality of the product after compression.
How does temperature and humidity influence the quality, stability and efficacy of pharmaceuticals? Thermal Analysis provides first information.
Deciding whether to purchase either a viscometer or a rheometer is not always straightforward. This guide will take you through the differences and how a rheometer could be more suited for your needs.
Amorphous calcium carbonate (ACC) is the amorphous and least stable polymorph of calcium carbonate. ACC is extremely unstable under normal conditions and is found for example in sea urchins and corals. The inﬂuence of ACC on the outstanding macromechanical properties of Echinoderm calcite is unknown. In this paper Thermal Analysis methods were used to investigate the thermal stability of sea urchin spines.
Additive Manufacturing (AM) has been around for several years. The main application for a long time was prototyping in the early stages of product development. Recently, new technologies like Digital Light Synthesis (DLS) are shaking up the AM sector. Using DLS and a two-stage dual-curing process, 3D printing is now being considered for mass production of parts since it has become considerably faster and the final product shows improved mechanical characteristics.
When making sure pharmaceuticals comply to quality standards, there are four areas where Thermal Analysis can help to determine potential problems. This article will explain those Terms.
Identify is the most comprehensive database system in Thermal Analysis! In a nutshell, Identify can be used for the recognition and comparison of measurement curves. Signals of types DSC, TGA, DIL/TMA and cp are supported, curves can be found and overlaid easily. This article highlights the great database contents of Identify (status 11/2019): The Identify database already contains about 2300 database entries!