Drug-excipient compatibility studies constitute an important phase in the development stage (pre-formulation) of dosage forms. They provide information whether physicochemical interactions happen between API (active pharmaceutical ingredient) and excipients. Differential scanning calorimetry (DSC) and thermogravimetry (TGA) are fast and easy-to-use methods to get first information about drug-excipient compatibility. For that, DSC and/or TGA measurements are … Read moreFast Compatibility Check by Means of DSC and SuperPosition
Compressibility of a pharmaceutical substance can lead to changes in its crystal structure, and thus in its properties (bio-availability, flowability, …). A DSC measurement verifies the quality of the product after compression.
How does temperature and humidity influence the quality, stability and efficacy of pharmaceuticals? Thermal Analysis provides first information.
Deciding whether to purchase either a viscometer or a rheometer is not always straightforward. This guide will take you through the differences and how a rheometer could be more suited for your needs.
Amorphous calcium carbonate (ACC) is the amorphous and least stable polymorph of calcium carbonate. ACC is extremely unstable under normal conditions and is found for example in sea urchins and corals. The inﬂuence of ACC on the outstanding macromechanical properties of Echinoderm calcite is unknown. In this paper Thermal Analysis methods were used to investigate the thermal stability of sea urchin spines.
Additive Manufacturing (AM) has been around for several years. The main application for a long time was prototyping in the early stages of product development. Recently, new technologies like Digital Light Synthesis (DLS) are shaking up the AM sector. Using DLS and a two-stage dual-curing process, 3D printing is now being considered for mass production of parts since it has become considerably faster and the final product shows improved mechanical characteristics.
When making sure pharmaceuticals comply to quality standards, there are four areas where Thermal Analysis can help to determine potential problems. This article will explain those Terms.
Identify is the most comprehensive database system in Thermal Analysis! In a nutshell, Identify can be used for the recognition and comparison of measurement curves. Signals of types DSC, TGA, DIL/TMA and cp are supported, curves can be found and overlaid easily. This article highlights the great database contents of Identify (status 11/2019): The Identify … Read moreSmart Thermal Analysis (Part IIb): Identify … the Most Comprehensive Database in Thermal Analysis
Carbon black is a virtually indispensable product for the polymer industry, whether in rubber mixtures as a strengthener, pigment for plastics, conductive agent or UV stabilizer, depending on the occurrence, particle size and structure. Therefore, it is crucial to evaluate and confirm its level and precise dispersion in order to avoid adverse effects on the final material costs and mechanical properties
Compatibility refers to harmony in a relationship, but is also an important term in science, be it in medicine where only a compatible organ can be transplanted to a recipient, or in computing to refer to software packages that can be used together. This concept is also well-known in the pharmaceutical field: Two components (e.g., … Read moreCompatibility of Drug and Excipient: Faster and Easier By Means of Thermal Analysis and SuperPosition