Compressibility of a pharmaceutical substance can lead to changes in its crystal structure, and thus in its properties (bio-availability, flowability, …). A DSC measurement verifies the quality of the product after compression.
The thermal stability of a substance is closely related to the shelf-life of pharmaceutical products. Here, the thermal stability of diclofenac sodium (anti-inflammatory) is determined by means of thermogravimetry.
When making sure pharmaceuticals comply to quality standards, there are four areas where Thermal Analysis can help to determine potential problems. This article will explain those Terms.
Thermal stability is a concept that is easy to conceive. But how to measure and quantify it? A fast and safe method for this is to use a thermobalance.
How to determine the shelf life of drugs without long time testing? First predictions about the shelf-life concerning thermal stability are achieved using thermogravimetric measurements with a kinetics Evaluation. This occurs within some hours or days.