Raw material identification or incoming goods inspection is of paramount importance for the quality and safety of drug products, wherever chemical substances are used in the pharmaceutical industry – maybe as an educt of chemical reactions or as a basis for further processing.
From the chemical point of view, diamonds are just made of carbon. The phenomenon that chemical elements can occur in different forms within the same phase, i.e., in different structural modifications, is called allotropy. Due to the relationship between crystal modification and melting point, Differential Scanning Calorimetry (DSC) is ideally suited to discriminate between different polymorphic forms. A more general term for chemical compounds is polymorphism.
Thermal Analysis provides powerful analytical methods for research, development and quality control of active pharmaceutical ingredients (APIs), excipients and formulations. Rheology perfectly complements the analytical equipment of your laboratory. Read more on the wide range of applications of DSC and Kinexus!
NETZSCH North America Commercial Testing Laboratory has set up a series of live demos based on questions we frequently hear in the field, at conferences and exhibitions about how our instruments work and the best measurements can be made. These demos are the short and sweet! Read more about the series and register for the first episode on 30 June 2020!
Compressibility of a pharmaceutical substance can lead to changes in its crystal structure, and thus in its properties (bio-availability, flowability, …). A DSC measurement verifies the quality of the product after compression.
The thermal stability of a substance is closely related to the shelf-life of pharmaceutical products. Here, the thermal stability of diclofenac sodium (anti-inflammatory) is determined by means of thermogravimetry.
When making sure pharmaceuticals comply to quality standards, there are four areas where Thermal Analysis can help to determine potential problems. This article will explain those Terms.
Thermal stability is a concept that is easy to conceive. But how to measure and quantify it? A fast and safe method for this is to use a thermobalance.
How to determine the shelf life of drugs without long time testing? First predictions about the shelf-life concerning thermal stability are achieved using thermogravimetric measurements with a kinetics Evaluation. This occurs within some hours or days.